#144
June 2nd
Potent new shingles vaccine
5-year trial shows shot for older adults reduces cases, pain
http://www.sfgate.com/cgi-bin/article.cgi?..MNGUOD27791.DTL
SanFranciscoChronicle,Thursday, June 2, 2005
A beefed-up version of the childhood chickenpox vaccine – given to adult volunteers over the age of 60 – significantly reduced cases of shingles, one of the most common and painful afflictions of old age.
The experimental vaccine made by New Jersey drugmaker Merck & Co. was tested in a five-year clinical trial. The results published today in the New England Journal of Medicine show it cut the number of shingles cases in half and reduced by two-thirds the most serious long-term complications of the illness.
Shingles is caused by a reactivation of the varicella-zoster virus – the virus that causes chickenpox. It can afflict people at almost any age, but of the 1 million cases that occur each year in the United States, more than half strike those older than 60, and the elderly appear to suffer the most severe outbreaks.
Among elderly shingles patients, about 1 in 8 suffers serious and debilitating pain for at least three months. Some shingles patients can suffer pain for more than a year and are prescribed narcotics to treat it.
"Shingles rarely takes a life, but it commonly takes away the quality of life’’
The experimental shingles shot is 17 times as potent as Merck’s Varivax, which was approved as a pediatric vaccine in 1995 and today sells for $69 per dose. Based on the results of this study, Merck on April 25 filed for Food and Drug Administration approval to market the vaccine under the name Zostavax.
http://www.sfgate.com/cgi-bin/article.cgi?..MNGUOD27791.DTL
Experimental Vaccine Helps Reduce Shingles
http://news.yahoo.com/s/ap/20050602/ap_on_…DI0BHNlYwNobA–
By STEPHANIE NANO, Associated Press Writer, Yahoo News, 54 minutes ago
…In the VA test, volunteers got the vaccine or a dummy shot and were followed for about three years. There were 315 cases of shingles in the group that got the vaccine, about half the 642 shingles cases in the group that didn’t, the researchers said.
The vaccine also reduced pain and discomfort by 61 percent and reduced long-term severe nerve pain, a serious complication, by two-thirds…
…“We will be evaluating how long the vaccine benefit lasts and … whether subsequent doses would be needed, and if so, when,” said Dr. Jeffrey L. Silber, who headed Merck’s research team for the study. …
Vaccine reduces cases of shingles
BBC News, Thursday, 2 June, 2005, 00:29 GMT 01:29 UK
http://news.bbc.co.uk/2/hi/health/4598929.stm
An “extra strong” chickenpox vaccine has cut cases of shingles in adults, US research has found.
Shingles is caused by a reactivation of the herpes zoster virus which causes the childhood illness.
It is most common in older people. The Herpes Virus Association estimates that by the age of 85, around 60% will have had shingles.
Many continue to suffer chronic nerve pain once the rash has subsided.
Professor Liz Miller, head of the Health Protection Agency’s immunisation department, said: “These results are very encouraging as they show that the vaccine can prevent shingles and reduce the severity of an attack”.
Judy Breuer, professor of virology at Barts and the London NHS Trust, told the BBC News website: “I would be very keen to see this vaccine used widely in the elderly, maybe in combination with the pneumonia or influenza vaccines.”